Of the inflammatory myopathies, dermatomyositis occurs in children and adults, polymyositis rarely occurs in children as a benign childhood myositis but is primarily at any decade in the adult years, and inclusion body myositis occurs most commonly in the elderly. An accurate diagnosis requires uptodate understanding of the clinical manifestations, different. Find powerpoint presentations and slides using the power of, find free presentations research about polymyositis dermatomyositis ppt. This chapter focuses on the major types of inflammatory myopathies im, including dermatomyositis dm. This chapter focuses on the major types of inflammatory myopathies im, including dermatomyositis dm, polymyositis pm, immunemediated necrotizing myopathy imnm, antisynthetase syndrome ass, and inclusion body myositis ibm table 3581. Polymyositis and dermatomyositis occur in about one person per 100,000. Proper diagnosis and treatment raise the chance of living life fully despite this illness. Clinical and histopathological distinctions between these conditions suggest that different pathogenic processes underlie each of the inflammatory myopathies. Inflammatory myopathies susan wallis, md idiopathic inflammatory myopathies polymyositis dermatomyositis juvenile dermatomyositis inclusion body myositis myositis. Inflammatory myopathies fact sheet national institute of. Introduction the inflammatory myopathies represent the largest group of. The iim are classified on the basis of patterns of presentation, age of onset, immunohistopathologic features, and response to treatment 36. The inflammatory process leads to destruction of muscle tissue, and is.
The juvenile idiopathic inflammatory myopathies jiim are a group of rare, chronic, autoimmune illnesses that affect muscle and, to a lesser extent, skin. Juvenile idiopathic inflammatory myopathies pediatric clinics. Multisystem inflammatory disease download powerpoint or pdf. View and download powerpoint presentations on myopathies ppt. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. It is part of the distinct disease entity of necrotizing myopathy, which has been added as an independent new domain to idiopathic inflammatory myopathy 6,7. A rare variant of idiopathic inflammatory myopathies show all authors. The diagnosis can be challenging because of the many potential clinical features and extramuscular manifestations, which may be seemingly unrelated. In a 6month, doubleblind, randomized, placebocontrolled trial, 29 patients with dm or pm improved significantly with oral creatine supplements 20 gd for 8 days, then 3 gd in conjunction with exercise as compared with exercise alone. In patients who have deteriorating strength, it is important to make note of whether the rate of progression is over days, weeks, months, or years. It is important to emphasize that not all myopathies with inflammation are classified as inflammatory myopathies. The two inflammatory myopathies include polymyositis and dermatomyositis. These features strongly suggested an inflammatory myopathy, but serum lactate abnormality and muscle biopsy established the unexpected diagnosis of a mitochondrial disease. Myopathies, polymyalgia rheumatica, and giant cell.
Except for juvenile dermatomyositis jdm, the idiopathic inflammatory myopathies are diseases of the adult. This section of the website hosts free arthritis powerpoint templates and free rheumatismpowerpoint templates specially designed for doctors, academicians, students and other professionals, who often need to create powerpoint presentations on arthritis for hospitals. Rheumatology at a glance download powerpoint or pdf. Paraneoplastic necrotizing myopathy associated with. Antibodies against signal recognition particles srp seen. Ppt inflammatory%20myopathies powerpoint presentation. In this chapter, we classify the toxic myopathies according to their presumed pathogenic mechanisms.
Muscle fibers may undergo necrosis as a result of the drug directly disrupting the sarcolemma, nuclear or mitochondria function, or that of other organelles. Apr 12, 2018 the idiopathic inflammatory myopathies iims. A free powerpoint ppt presentation displayed as a flash slide show on id. Idiopathic inflammatory myopathies iim are a rare group of sporadic myopathies with annual incidence of approximately 1 in 100 000.
Welcome to s free arthritis powerpoint templates section. Powerpoint presentation inflammatory bowel disease. A range of tools are available to evaluate outcomes. A myopathy is a muscle disease, and inflammation is a response to cell damage. Ppt neuromuscular disorders, myopathies powerpoint. Although their clinical presentations aside from the presence of certain skin findings in dermatomyositis, some of which are pathognomonic and treatments are similar, the two diseases are pathologically quite distinct. Idiopathic inflammatory myopathies iim are a heterogeneous group of acquired immunemediated diseases, which typically involve the striated muscle with a variable involvement of the skin and.
Medications can have either a direct or an indirect adverse effect on muscle. Inflammatory myopathies information page national institute. Myopathies are diseases characterized by primary muscle pathology. Methods an international, multidisciplinary group of myositis experts produced a set of 93 potentially relevant variables to be tested for inclusion in the criteria. Mitochondrial myopathy with atypical subacute presentation. Lung manifestations in the rheumatic diseases chest. Ppt inflammatory myopathies powerpoint presentation. The peak time to get them, though, is ages 5 to 10 in children, and 40 to 50 in adults. It is important to be aware that the term often is used to refer to all myopathies, inflammatory or not, and that it can not be taken to imply an inflammatory etiology. Dermatomyositis dm polymyositis pm autoimmune necrotizing myopathy nm inclusion body myositis ibm. Exercise is an important part of treatment in patients with idiopathic inflammatory myopathies. Most myopathies tend to present with shoulder and hip girdle weakness.
Inflammatory myopathies harrisons principles of internal medicine. Idiopathic inflammatory myopathies a guide to subtypes. Although the condition can be diagnosed at any age, idiopathic inflammatory myopathy most commonly occurs in adults between ages 40 and 60 years or in children between ages 5 and 15 years. The idiopathic inflammatory myopathies are characterized by muscle weakness and inflammation. The inflammatory myopathies are a group of diseases that involve chronic longstanding muscle inflammation, muscle weakness, and, in some cases, muscle pain. While this pattern recognition approach to myopathy may have. Definition myopathies are disorders with structural changes or functional impairment of muscle.
Worldwide incidence of inflammatory myopathies is about 510 per 100,000 people. The most common muscle symptom caused by statins is muscle pain or myalgia and it occurs in about 7% of. Idiopathic inflammatory myositis iim is a group of rare connective tissue diseases ctds characterised by muscular and extramuscular signs, in which lung involvement is a challenging issue. This spectrum of clinical presentation has led to this separate and unique subcategory of iims 4. Improved functioning, ability to perform activities of daily living, and healthrelated quality of life have been reported in adult polymyositis, dermatomyositis, and also recently inclusion body myositis following different exercise regimens, with no signs of increased muscle inflammation. The most common types are dermatomyositis dm, polymyositis pm, necrotizing autoimmune myopathy nam. Objective to describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies iims and their major subgroups. Inflammatory myopathies are a heterogeneous group of chronic systemic autoimmune diseases with an annual incidence of two to five cases per million, characterized by muscle inflammation and progressive muscle weakness. Idiopathic inflammatory myopathies is the property of its rightful owner.
Due to the variety of clinical features, age ranges of presentation and systemic. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. The inflammatory myopathies associated with srp and 200100 antibodies do not even necessarily have the inflammatory muscle infiltrates that we traditionally associate with inflammatory myopathies. Dc are the most efficient professional antigenpresenting cells apc, which are critical for the development of innate and adaptive immune responses. Interstitial lung disease associated with the idiopathic inflammatory myopathies. Idiopathic inflammatory myopathy refers to a group of conditions that affect the skeletal muscles muscles used for movement. Introduction largest group of potentially treatable myopathies in children and adults. Inclusion body myositis ibm is the most common idiopathic inflammatory myopathy occurring in patients over the age of 50 years and probably accounts for about 30% of all inflammatory myopathies. Dm and ibm are rather homogeneous clinically and histologically. This patient had two uncommon features for primarily mitochondrial myopathies.
Idiopathic inflammatory myopathies myositis request pdf. Other im include those caused by infection, eosinophilic myositis and granulomatous myositis. Evaluation and management of low back pain download powerpoint or pdf. Myopathies can be classified as hereditary or acquired. The direct effect can be focal, as might occur secondary to a drug being injected into tissue, or more commonly generalized. Idiopathic inflammatory myopathy is a group of disorders characterized by inflammation of the muscles used for movement skeletal muscles. Inflammatory myopathy is disease featuring weakness and inflammation of muscles and in some types muscle pain. The inflammatory myopathies are a group of disorders sharing the common feature of immunemediated muscle injury.
Ppt neuropathies, myopathies powerpoint presentation. Necrotic arrow and regenerating fibers arrowheads are present. Unlike the idiopathic interstitial pneumonias, patients with rheumatic diseases experience lung disease in the context of a systemic disease that may make it more difficult to recognize and that may present greater risks with treatment. Inflammatory myopathies neuromuscular disorders, 2e.
The inflammatory myopathies myositis encompass a heterogeneous group of chronic muscle disorders of unknown origin and with varying prognoses. Dec 28, 2017 myopathy is a muscle disease unrelated to any disorder of innervation or neuromuscular junction. This medical powerpoint template will fit presentations on hands inflammatory diseases, arthritis, rheumatoid joint inflammation, rheumatism, joint pain, joint traumas, etc. Lung ailments in rheumatic diseases present unique challenges for diagnosis and management and are a source of significant morbidity and mortality for patients. If so, share your ppt presentation slides online with.
The national institue of neurological disorders and stroke ninds, along with other agencies within the national institutes of health nih, conducts and supports a wide range of research on neuromuscular disorders, including myositis and the inflammatory myopathies. Rheumatology, dermatology, neurology and paediatric. Inflammatory myopathies harrisons principles of internal. It does not include upper motor neuron lesions, lower motor neuron lesions, myasthenia gravis which also causes muscle weakness. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Jul 06, 2011 myopathies a special and seperate entity with specific features in each disorder making us easy for diagnosis,confirmation by muscle biopsy. Idiopathic inflammatory myopathies iim are a group of chronic, autoimmune conditions affecting primarily the proximal muscles. In some cases, the combination of multiple myopathic agents is responsible for the acute deterioration. Polymyositis and dermatomyositis are systemic disorders of unknown cause whose principal manifestation is muscle weakness. The inflammatory myopathies are a group of muscle diseases that involve inflammation of the muscles or associated tissues, such as the blood vessels that supply the muscles. Exercise in inflammatory myopathies, including inclusion. Exercise in inflammatory myopathies, including inclusion body. Chandan n intern, department of medicine, mims, mandya 2. Scribd is the worlds largest social reading and publishing site.
Inflammatory myopathies information page what research is being done. The cause of much inflammatory myopathy is unknown, and such cases are classified according to their symptoms and signs and electromyography, mri and laboratory findings. Chemokines are important mediators of the immune response as they regulate. Polymyositis may begin abruptly, but the usual presentation is one of progressive muscle weakness over weeks to months.
Muscle inflammation and weakness occur in both conditions while patients with dermatomyositis also have a rash. Ppt inflammatory myopathies powerpoint presentation, free. Download figure open in new tab download powerpoint. Classification, diagnosis, and management of idiopathic. Leg weakness eg, difficulty in rising from a chair or climbing stairs typically precedes arm symptoms. Information about the progression of the disease process is very important in helping to classify the specific etiology of myopathy. Steroids, lipidlowering agents, retroviral agents, alcohol, colchicine, pentachlorophenol pcp, heroin, and a myriad of other medications may cause myopathies. Idiopathic inflammatory myopathies and the lung european. Paraneoplastic necrotizing myopathy is a rare condition associated with cancer and characterized by massive necrosis of muscle fibers in the absence of significant inflammation 111. Inclusion body myositis, a gradual and insidious loss of muscle mass and strength associated with a characteristic histology and normal to mildly elevated muscle enzyme levels, is the most common form of inflammatory. Recent concepts in inflammatory myopathies krushna chandra pani ipsita panda 2. Interstitial lung disease associated with the idiopathic. Idiopathic inflammatory myopathies iims, except for sporadic inclusion body myositis sibm, present with subacute symmetrical weakness of the limb girdle muscles, an elevated serum creatine kinase activity, and inflammatory cells in the muscle biopsy necrotizing autoimmune myopathy being an exception.
The primary clinical manifestation of a myopathy is weakness, and accompanying symptoms can include but are not limited to wasting, cramps, spasms, myoclonus, contractures, and fatigue. Nam is a subgroup of inflammatory myopathies characterized pathologically by necrotic muscle fibers with absent or minimal inflammation. The idiopathic inflammatory myopathies are rare sporadic disorders. Mar 12, 2020 inflammatory myopathies information page what research is being done. Idiopathic inflammatory myopathy genetics home reference nih. Women get inflammatory myopathies about twice as often as men. The idiopathic inflammatory myopathies are a group of conditions characterised by inflammation of muscles myositis and other body systems.
Find powerpoint presentations and slides using the power of, find free presentations research about myopathy ppt. View and download powerpoint presentations on myopathy ppt. Find powerpoint presentations and slides using the power of, find free presentations research about myopathies ppt. Neuromuscular disorders, myopathies zsuzsanna ar nyi neuromuscular disorders radiculopathies plexopathies mononeuropathies polyneuropathies motoneuron diseases. Trichromestained sections of quadriceps muscle demonstrate increased variability of muscle fiber size. Interstitial lung disease ild is the hallmark of pulmonary involvement in iim, and causes morbidity and mortality, resulting in an estimated excess mortality of 50% in some series. Joint exam and injection techniques download powerpoint or pdf. On the other hand, what has been called pm in the literature is likely a heterogeneous group of disorders. The discovery of novel autoantigen systems related to idiopathic inflammatory myopathies collectively referred to as myositis in adults and. The idiopathic inflammatory myopathies iims are a group of autoimmune conditions characterised. Introduction inflammatory myopathies are sporadic disorders representing the largest group of acquired and potentially treatable causes of skeletal muscle weakness. There are four major categories of idiopathic inflammatory myopathy.
Diffuse arthralgias and myalgias download powerpoint or pdf. Introduction classification clinical features extramuscular features differential diagnosis laboratory diagnosis histopathology serology outline 3. Chemokines and dendritic cells in inflammatory myopathies. The antisynthetase syndrome associated with antibodies described in this section does not cleanly sort under either the dermato or polymyositis labels.
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